Mixing AstraZeneca and Pfizer vaccine leads to better immune response, research shows
Share article:
Share article:

Mixing AstraZeneca and Pfizer vaccine leads to better immune response, research shows

Different coronavirus vaccines by Pfizer/BioNTech, Moderna and AstraZeneca. Credit: Belga

People who receive a second shot of the Pfizer/BioNTech vaccine after they got a first dose of AstraZeneca’s jab develop better protection against the coronavirus than after getting a second AstraZeneca dose, new research shows.

The study, conducted by researchers from the German University of Saarland, followed 250 people, some of whom were fully vaccinated with AstraZeneca or Pfizer, and others who received a combination. The interval between the first and second shot was nine to twelve weeks.

“We not only examined how many antibodies they had formed against the coronavirus in the vaccinated people, but we also determined the strength of the so-called neutralising antibodies,” said Professor Martina Sester from the University of Saarland.

“This tells us how well the antibodies prevent the virus from entering the cells,” she stated, adding that 10 times more antibodies were found in the blood after a double Pfizer vaccination and a combination shot than after two AstraZeneca shots.

Related News:

 

The combination gave even better results in terms of neutralising antibodies than a double shot with Pfizer, according to the researchers.

Finally, getting both shots with Pfizer, or a combination of AstraZeneca and Pfizer, leads to a stronger reaction of the so-called t-cells, which help to produce antibodies and prevent a severe disease progression after a Covid infection.

In several European countries, a first shot of AstraZeneca is currently already followed a few weeks later by a second shot with Pfizer or Moderna in some cases.

In France, the decision to switch to a different vaccine after a first shot of AstraZeneca was made in early April, after reports that the jab could be linked to rare blood clots.

At that stage, however, this strategy of mixing the vaccines had not been scientifically investigated, but the results of the first studies – which have not yet been peer-reviewed – now state that it leads to an excellent immune response, and does not cause any severe side effects.

In Belgium, someone who received their first shot of AstraZeneca’s vaccine will also receive a second shot of the same jab – as recommended by the European Medicines Agency (EMA).

While changing course now might be possible, it would also be “a logistical nightmare,” according to professor of Vaccinology Corinne Vandermeulen (KU Leuven).

“These studies are particularly important for the third dose,” she told De Standaard. “Now we know that we probably do not need to take into account which vaccine someone got first.”

Latest news

Anti-vaxxers demonstrate against Covid Safe Ticket in Brussels
Hundreds of supporters of the anti-vaxx movement gathered on Saturday outside the headquarters of the Pfizer pharmaceutical company to protest ...
Belgium’s investment funds total 260 billion euros in assets
Belgium’s funds industry grew by 5.3% (13 billion euros) in the second quarter of this year, bringing investment funds available to the public to ...
Brussels to Luxembourg by train in two hours soon possible
The fastest train ride between Brussels and Luxembourg currently takes almost three hours, but that could be slashed to about two hours thanks to the ...
Daily Covid infections up by almost 30% in Belgium
Between 6 and 12 October, an average of 2,438 people were infected with the Covid-19 virus every day, according to figures from the Sciensano public ...
Over 80,000 companies in Belgium non-compliant with anti-money laundering meassures
Over 80,000 companies and non-profits in Belgium are still not compliant with the Ultimate Business Owner (UBO) register, which is required of them ...
Increase in tax exemption for donations in Belgium fails to meet expectations
The increase from 45% to 60% in the tax exemption for donations, decided by the former federal government in June 2020, has cost Belgium more than ...
Sex workers in Belgium to get more social rights protection
The social rights of sex workers will soon be better protected in Belgium, Belga News Agency reports. The Council of Ministers has approved a draft ...
Belgian firms sent almost 266 billion euros to tax havens last year
Hundreds of Belgian firms sent close to 266 billion euros to tax havens last year, De Tijd reported on Saturday. Any Belgian individual or firm ...
Belgian investigator wins prestigious US prize
Olivier Hardy, an investigator with the federal police’s anti-terrorist unit in Brussels, DR3, received on Friday a "Top Cop" prize in Washington for ...
Pegasus Project: European Parliament awards journalism prize to investigation of use of spyware
The Daphne Caruana Prize for Journalism was awarded on Thursday to the journalists from the Pegasus Project coordinated by the Forbidden Stories ...
Belgians can now test their knowledge of driving rules and win prizes
The Walloon Road Safety Agency (AWSR) launched on Friday a quiz to allow the general public to test their knowledge of the highway code. Last year, ...
600 extras wanted for film about Belgian ‘Porn King’ and notorious Antwerp nightclub
A Belgian movie telling the story of a notorious Antwerp nightclub with connections to a Belgian 'Porn King' is looking for 600 extras at the end of ...